GLP1s and Sleep Apnea

GLP1s (in particular Tirzepatide, created by Eli Lilly) have positive effects on Sleep Apnea

GLP1s and Sleep Apnea
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GLP1 Receptor Agonists help the majority of people that take them lose weight. At this point, this much is well known, researched and studied.

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Don't know what a GLP1 Receptor Agonist is, or how drugs like Ozempic, Mounjaro, Wegovy, or Zepbound work?

Check out our quick explainer

What is less studied even today, are the various effects that GLP-1 has on the body, and the intricate web of interactions that the hormones in your body undertake.

Somewhat unsurprisingly, GLP1 Receptor agonists like Ozempic, Wegovy, Mounjaro, Zepbound and others have been found to reduce Sleep Apnea

Sleep apnea - Wikipedia

GLP1 reduces Sleep Apnea by 55% in study by Eli Lilly

One of the first companies to press with this news was Eli Lilly:

Tirzepatide reduced sleep apnea severity by up to nearly two-thirds in adults with obstructive sleep apnea (OSA) and obesity | Eli Lilly and Company
The Investor Relations website contains information about Eli Lilly and Company’s business for stockholders, potential investors, and financial analysts.

Eli Lilly produces a formulation of GLP-1 receptor agonist called Tirzepatide, which is present in Mounjaro and Zepbound.

Pens of Mounjaro and Zepbound, side by side (source: lifestylemedicalcenters.com)

How dangerous is Sleep Apnea?

Sleep Apnea is a surprisingly common yet under-appreciated impediment to life quality that can be associated (and possibly lead to) death.

Sleep Apnea is so important, Shaquile O'Neal (a famous American Basketball player) has taken part in teamed up with Harvard in the past to reduce the occurrence:

According to the National Council on Aging, approximately 39 million people in the USA have Sleep Apnea, with an estimated 900 million people worldwide having mild to severe sleep apnea.

Sleep Apnea Statistics and Facts You Should Know
An estimated 39 million U.S. adults have sleep apnea. We researched up-to-date statistics and facts on this common sleep disorder.

While Sleep Apnea does not directly cause death in most cases, it can be a contributing factor, in particular to heart disease.

Tirzepatide helps, but what about Semaglutide?

While the way the drugs work are similar, there are differences, which we've covered in the past:

Semaglutide (Ozempic) vs Tirzepatide (Mounjaro)
Learn the major differences between Ozempic (Semaglutide) and Mounjaro (Tirzepatide)

We expect (and hope) that the benefits seen here by Tirzepatide to be replicated by other GLP-1 Receptor Agonists, as the mechanism by which they work is similar (hence the classification).

Of course, until we can get more clinical and/or trial results, this is only a hunch.